• Effectively Clears Blood and Blood Residual with Low Flush Volumes
  • Does not Require a Change in Clinical Practice or Technique
  • Saline Flush Option can Eliminate the use of Heparin
  • Minimal Blood Reflux in the Catheter Tip
NanoClave™ Low Profile Needlefree Connector

The NanoClave™ Needlefree connector is your perfect choice for neonatal and pediatric patient infusion connections. The NanoClave™ minimal flush volume will help you maximize your patient’s safety.


The NanoClave is specifically designed for your delicate neonatal and pediatric patients. You make every effort to keep them safe from infection while effectively managing their fluids, NanoClave can help with minimal flush volumes, a straight and clear fluid path, and a proven design that is mechanically and microbiologically closed.

The design of your needlefree intravenous (I.V.) connectors plays a substantial role in your ability to limit hospital-acquired bloodstream infections (HA-BSI). The neutral displacement straight fluid path design, split-septum and minimal dead space of the NanoClave work together to help minimize blood reflux into the tip of the catheter upon connection or disconnection of the luer. Not only does the NanoClave provide enhanced patient safety through innovative technology but it has also been proven to provide an effective microbial barrier against bacteria transfer and contamination.


Unique features of the NanoClave™ that may help reduce the risk of bacterial contamination:
  • Can be used on all peripheral, arterial, and central venous catheters for the administration of IV fluids or medications, and can be used with blood products.
  • Clear housing allows for visualization of the internal fluid path upon flushing the connector.
  • Effectively clears blood and blood residual with low flush volumes.
  • Minimal blood reflux in the catheter tip upon connection or disconnection of a luer.
  • Clamping sequence not required, reducing educational burden and risk of error.
  • Allows a saline flush option, which can eliminate the risk of Heparin Induced Thrombocytopenia (HIT).


Accessing the Fluid Path

  1. When NanoClave™ is not being accessed, the silicone seal forms a safe, swabbable barrier to bacterial ingress.
  2. Upon luer access, the silicone seal is depressed and the fluid path windows are exposed through the device's split septum.
  3. Fluid is either infused or aspirated through the connector and catheter via the dedicated straight internal fluid path.



Catalog Number Description
011-A1000 NanoClave™ Low Profile Neutral Displacement Connector, flow rate 145 mL/min, dead space 0.02 mL, compatible with blood, lipids, alcohol, chlorhexidine and chemotherapy. DEHP and latex free. 100/case
011-A1001 6" (15 cm) Smallbore extension with NanoClave™ T-Connector, clamp and rotating luer. DEHP and latex free. 50/case
011-A1002 6" (15 cm) Smallbore extension with NanoClave™ T-Connector, clamp and luer Slip. DEHP and latex free. 50/case
011-A1003 6" (15 cm) Smallbore extension with MicroClave® Clear connector and NanoClave™ T-Connector, clamp and rotating luer. DEHP and latex free. 50/case
011- A1004 5" (13 cm) Standardbore extension with NanoClave™ T-Connector, clamp and rotating luer. DEHP and latex free. 50/case
011-A1006 13" (33 cm) Smallbore extension with 2 “Y” ports with NanoClave™, one 0.2 μ filter, 2 clamps and rotating luer. DEHP and latex free. 50/case
011-A1007 7" (18 cm) Smallbore extension with MicroClave® Clear connector, “Y” port with NanoClave™ connector, clamp and rotating luer. DEHP and latex free. 50/case
011-A1008 7" (18 cm) Smallbore extension with MicroClave® Clear connector, “Y” port with NanoClave™ connector, clamp and luer lock. DEHP and latex free. 50/case
011-A1009 7" (18 cm) Smallbore extension with a removable MicroClave® Clear connector, one NanoClave™ T-connector, clamp and rotating luer. DEHP and latex free. 50/case
011-A1013 10" (25 cm) Standardbore trifuse extension with 3 MicroClave® Clear connectors, with NanoClave™ T-Connector, with 4 clamps (Red, White and Blue) and rotating luer. DEHP and latex free. 50/case
011-A1014 8" (20 cm) Smallbore extension with a MicroClave® Clear connector, a 0.2 μ filter, a NanoClave™ T-connector, clamp and rotating luer. DEHP and latex free. 50/case

Distributed by Victus, Inc.

All technical information obtained from the manufacturer’s website and technical sheets.

Residual Volume 0.02 mL
Flow Rate at Gravity 145 mL /minute
Blood Compatibility Yes
MRI Compatibility Yes
High Pressure Compatibility N/A


Alcohol Yes
Lipids Yes
Chlorhexidine Yes
Chemotherapy Yes


Disinfect to Protect

  • When placing a new NanoClave™ on a catheter, disinfect the catheter hub and prime the NanoClave™.
  • Before accessing a NanoClave™, always disinfect the injection site with the approved antiseptic per facility protocol.
  • Scrub the injection site in accordance with facility protocol for appropriate scrubbing and dry times.

Administer or Aspirate

  • Attach IV tubing, syringe or blood tube holder to NanoClave™ by inserting the luer and twisting ¼ turn, or until a friction fit is achieved.
  • Do not over-tighten a luer beyond the friction fit as this may damage both the luer and the NanoClave™.
  • To disconnect, grasp NanoClave™ and then twist the mating luer away from NanoClave™ until loose. Do not hold catheter hub during disconnect as this may cause accidental removal of NanoClave™ from hub.

Flush After Each Use

  • Flush the NanoClave™ with normal saline or in accordance with facility protocol. After blood use, the NanoClave can be flushed clean and does not require change-out.
  • Use routine flushing in accordance with facility protocol in order to maintain catheter patency.
  • Change NanoClave™ in accordance with facility protocol and CDC guidelines.




Can needles be used with NanoClave™?
NanoClave™ is totally incompatible with the use of needles and caps. It’s a better system since it succeeds in reducing the risk of accidental inoculation by preventing the use of needles. The NanoClave™ can only be activated with a male luer, NEVER with a needle.


What happens if I use a needle with NanoClave™?
The needle will pierce the silicone seal and a leak will occur.


What if this situation occurs?
The only solution is to change the NanoClave™.


Can we use the NanoClave™ with all Luer connectors?
Yes, provided that the connectors are ISO luer Lock or ISO luer Slip (99% of the connectors on the market are of this type). It connects to all female luer connectors (lines, catheters, valves, extensions, etc.).


When should I change the NanoClave™?
The NanoClave™ should be changed according to each institution's protocols. In bacteriological studies, the NanoClave™ has been shown to stay sealed for up to 7 days in arterial as well as venous lines. The NanoClave™ has shown to maintain its seal for 144 activations in 144 hours.


Can I use a cap with the NanoClave™?
The NanoClave™ does not require caps. In addition, a cap can rupture the polycarbonate spike. The silicone seal withstands more than 3000 mmHg of pressure and acts as a bacterial barrier (after being disinfected). The NanoClave™ is impermeable to air and water and a cap can keep it open.


What can I use to clean the NanoClave™?
The NanoClave™ has been proven to be totally compatible with povidone-iodine, isopropyl alcohol, Betadine, and chlorhexidine.


Do we need to flush the NanoClave™ after an extraction or an infusion?
Always follow the hospital's protocol. It is highly recommended that the NanoClave™ be flushed after an infusion or an extraction.


Is the NanoClave™ effectively flushed after a blood infusion?
Flushing with saline solution after the extraction or infusion of blood is highly effective in the NanoClave™.

  • Breznock E M, DVM, PhD, Diplomate ACVS, Sylvia C J, DVM, MS., BioSurg, Inc. The in vivo evaluation of the flushing efficiency of different designs of clear needlefree connectors, March 2011.
  • Jarvis W., MD. Choosing the Best Design for Intravenous Needleless Connectors to Prevent Bloodstream Infections. Infection Control Today, August 2010
  • Ryder M, RN, PhD. Bacterial transfer through Needlefree connectors: Comparison of nine different devices. Poster presented at the Annual Society for Healthcare Epidemiology of America (SHEA) conference 2007, Abstract 412. 
  • Moore C, RN, MBA, CIC. Maintained Low Rate of Catheter-Related Bloodstream Infections (CR-BSIs) After Discontinuation of a Luer Access Device (LAD) At an Academic Medical Center. Poster presented at the annual Association for Professionals in Infection Control and Epidemiology (APIC) Conference 2010, Abstract 4-028. 
  • Guideline for the Prevention of Intravascular Catheter-Related Bloodstream Infections, Final Issue Review, May 17, 2010
  • Data on file at ICU Medical. Low Volume Flush Characteristics of Unique Needlefree Connectors M1-1223 Rev. 1.


  • Developing a Closed, Intravenous Medication System for a Neonatal Intensive Care Unit: Tanner J, Neonatal Intensive Care Journal, July-August 2012
  • A needleless closed system device (Clave®) protects from intravascular catheter tip and hub colonization: a prospective randomized study Bouza E, Munoz P, Lopez-Rodriguez J, Jesus Perez M, Rincon C, et al. J Hosp Infect. 2003; 54:279–287

Clinical Reports

  • The in vivo evaluation of the flushing efficiency of the NanoClave™ low-profile neutral displacement connector compared to two other connectors commonly used on central and PICC lines Eugene M. Breznock, DVM, PhD, Diplomate ACVS, Charles J. Sylvia, Jr., DVM, MS, BioSurg, Inc., 2011

NanoClave™ Low Profile Neutral Displacement Connector